Research!America Hosts NTD Forum at Tulane University

On May 15, Research!America hosted a forum, “Neglected Tropical Disease Research in Louisiana: Saving Lives and Creating Jobs.” The forum, featuring leading NTD experts from the region, was held at Tulane University School of Public Health and Tropical Medicine in New Orleans.

NTDs Louisiana Forum

Pierre Buekens, MD, PhD, dean of the Tulane University School of Public Health and Tropical Medicine, addresses forum attendees.

Pierre Buekens, MD, PhD, dean of the Tulane University School of Public Health and Tropical Medicine, made opening remarks. He set the scene for the day, reminding us that there is a false divide between global and domestic health. Dr. Buekens pointed out that borders don’t matter when we share climates and that NTDs can affect people in all corners of world, including New Orleans. He argued that the US is not doing enough to address the threat of NTDs and said that it is “really time to wake up, we really can’t tell other countries what to do if we don’t address it at home.”

The first panel focused on NTDs and NTD research in the U.S. and Louisiana in particular. The panel was moderated by Dean Buekens and featured the following panelists: Patricia Dorn, PhD, Professor of Biological Sciences at Loyola University New Orleans; John B. Malone, DVM, PhD, Professor of Pathobiological Sciences at Louisiana State University; Raoult C. Ratard, MD, State Epidemiologist at the Louisiana Department of Health and Hospitals and Dawn Wesson, MS, PhD, Associate Professor of Tropical Medicine at Tulane University.   Continue reading →

Researchers announce successful cloning of human stem cells

Photo © OHSU

A group of scientists at Oregon Health & Science University (OHSU) — a Research!America member — recently announced that it had successfully generated cloned embryonic stem cells from skin cells of an adult and an unfertilized human egg. Like other stem cell technologies, these cloned stem cells may one day be used for therapeutic purposes — replacing failed organs or damaged nerves.

Research into this area had been ongoing for several years; until now, scientists’ efforts were unsuccessful. Continue reading →

A Weekly Advocacy Message from Mary Woolley: A bad year to have a good idea?

Dear Research Advocate,

“2013 is a bad year to have a good idea,” was the bleak statement Laura Niedernhofer, MD, PhD, made about the impact of sequestration in a recent FASEB report. None of us want this year, or this country, to be a bad starting point for good ideas … but that’s what’s at stake. Think about telling someone with a serious illness that this isn’t a good year, or a good decade, for research. Think about telling them that from here on out, it may always be a bad year for a good idea.

Is there hope for turning this around? We have bipartisan support and we have champions; that we need more is a reality, but by no means an impossibility. Cancer research advocates gathered last evening to honor Congresswoman DeLauro (D-CT-03) and Senator Shelby (R-AL). Several other Members of Congress gave inspiring remarks, with an emphasis on adopting a positive, can-do approach, focusing on the local impact of research and stressing the profound and enduring consequences of backtracking. They counseled advocates, “Don’t take no for an answer!” In yesterday’s NIH appropriations hearing, Chairwoman Mikulski (D-MD) vowed to “work her earrings off” to make sure the agency gets the funding it needs. Strong bipartisan support for research was the byword for the session.

Other Members of Congress are speaking up for research. Rep. Earl Blumenauer (D-OR-03), Chair of the Congressional Neuroscience Caucus, fired up the One Mind Summit for brain research on Tuesday. He spoke about how one constituent’s advocacy, reinforced by Congressman Patrick Kennedy (a member of the Research!America Board) converted his passive support of research to active advocacy. Advocates’ persistence pays off! Meanwhile, Rep. Randy Hultgren (R-IL-14) and Rep. Rush Holt (D-NJ-12) are circulating a Dear Colleague letter urging continued support for the Department of Energy’s Office of Science. It has bipartisan support, garnering more than 70 signatures. And a bipartisan team (Reps. Lamar Smith [R-TX-21] and Zoe Lofgren [D-CA-19] and Sens. Mazie K. Hirono [D-HI] and Roger Wicker [R-MI]) has introduced H.R. 1891 to create an honorary U.S. science laureate. Read the press release here. Bravo to these visionary leaders. Write to your representatives now. If they aren’t already champions, maybe your advocacy will do the trick!

But this week’s letter is not all about congressional advocacy; it’s about necessary change in the science enterprise, as discussed in The American Academy of Arts and Sciences report titled “ARISE II: Unleashing America’s Research & Innovation Enterprise.” The report succinctly contrasts the history of the physical and engineering sciences with that of the life sciences and medicine. The report highlights the critically important role of industry as critical to future partnerships between and within these fields. There is sober reflection that sustaining innovation at this juncture will require “change in many places.” The authors, who include co-chair Keith Yamamoto, PhD, of UCSF (and a Research!America Board member) don’t have in mind change by elected officials; they are speaking first and foremost to the members of the research ecosystem. I hope you will take the time to review this compelling report.

Our Chairman, The Honorable John E. Porter, is featured in Chemical and Engineering News discussing the importance, now more than ever, of scientists educating policy makers about the necessity of research for our future and our economy. Mr. Porter will receive an honorary degree from Morehouse School of Medicine this weekend — well-deserved recognition for his work as an untiring champion of research!

No year should be a bad one for a good idea! Take Mr. Porter’s advice and speak up. Don’t hesitate to contact me if Research!America can be of assistance as you fight the good fight.

Sincerely,

Mary Woolley

John Edward Porter, Chairman of Research!America, says Scientists Must Take on Broader Role in Advocacy

Hon. John Edward PorterThe chair of Research!America’s board of directors, John Edward Porter, tells Chemical & Engineering News that he began college with the aspiration of becoming an engineer or scientist. As fate would have it, he turned his focus instead to pursuing a law degree. He never lost his passion for science, though. That passion is evident in his efforts as a champion for research while in Congress and in his work with Research!America. Now he is charging scientists to take on a broader role in science advocacy.

In an era of flat-funded budgets and sequestration, Porter says it’s important for scientists to engage more with policy makers, most of whom are lawyers by trade.  Porter acknowledges that engaging with the public and taking on the role of an advocate may be very uncomfortable and unnatural to scientists, but it is a vital step to ensuring the U.S. maintains a position of world leadership. To be an effective advocate doesn’t mean scientists only have to ask for more money; advocacy and engagement can be accomplished through a range of activities. Continue reading →

May 12-18 is National Women’s Health Week

The U.S. Department of Health and Human Services is marking a week-long observance of Women’s Health. In a statement about 2013’s National Women’s Health Week, HHS Secretary Kathleen Sebelius points to the role of women as health care decision-makers in their families. Mothers, wives and daughters are often the first and primary care giver when a family member falls ill, and yet many women may overlook their own personal health. Continue reading →

Research!America and Global Health Experts Focus on the Economic and Health Burden of Neglected Tropical Diseases in the U.S.

Leading researchers discuss emerging health threats at panel discussion

During a panel discussion today at Tulane University’s School of Public Health and Tropical Medicine, hosted by Research!America, several researchers and leading public health experts said the nation must increase public awareness and research to address the emergence of neglected tropical diseases (NTDs) in the U.S.

NTDs, commonly associated with the developing world, have recently been identified in many parts of the country including Louisiana. Factors such as increased globalization, trade, migration, urban sprawl or climate change have been cited as potential underlying causes for the emergence of NTDs in the U.S. Chagas disease, which can cause heart failure, affects more than 300,000 people across the nation and costs the U.S. an estimated $1 billion in health care and lost productivity each year. Researchers at Loyola University New Orleans identified the first locally acquired case of Chagas disease in Louisiana. Continue reading →

Member Spotlight: The American Society for Tropical Medicine and Hygiene

Karen Goraleski

Karen Goraleski

By ASTMH Executive Director Karen A. Goraleski

The American Society for Tropical Medicine and Hygiene is an international organization comprised of scientists, clinicians and program professionals who work to promote global health through the prevention and control of infectious diseases. ASTMH recognizes that global health is America’s health and America’s health is global health. It is vitally important for the broad research community – from basic through implementation and evaluation – to actively support a vibrant and innovative research enterprise. Everyone benefits from a strong U.S. investment in research. Continue reading →

Existing “brain drain” a reality for sciences, worsened under sequestration

In 2012, months before sequestration was enacted, scientists were already pressed to find jobs. Take the example of “Rebecca,” whose story was featured in a recent Huffington Post article. She had completed her PhD in chemistry and was working in an academic research laboratory. When her lab didn’t get a new grant to allow her to continue the research, she ended up unemployed. In an already tough financial environment, she spent three months looking for employment in research, hoping to utilize her hard-earned doctoral degree. Continue reading →

National Stroke Awareness Month

A Presidential Proclamation in 1989 launched National Stroke Awareness month which is celebrated every May. Strokes occur when a blood vessel in the brain is clogged or bursts, preventing oxygen-rich blood from reaching an area of the brain. A number of factors can increase someone’s risk of stroke; including lifestyle choices that affect our cardiovascular health. But there are more complex factors including an individual’s genetic composition, age and gender. And risk factors for women can be different from those for men. You can learn more about these risk factors from the American Heart Association and American Stroke Association. Continue reading →

Neglected Tropical Diseases hit closer to home

Based on their name, you might think that neglected “tropical” diseases (NTDs) aren’t something American physicians would encounter often. While that may have been true in the past, there is a growing threat of tropical illnesses spreading through the U.S. Many factors may contribute to the rise in incidence, but the bottom line is a very real health threat that the American medical community may not be prepared to face.

Take the story of Maira Gutierrez, for example. A resident of the U.S. for over 30 years, she found out she was infected with Chagas, a neglected tropical disease, after she donated blood. For years, no medical professional could provide more than cursory information about her disease, nor prescribe a treatment. Just like her diagnosis, she felt “neglected” by the medical community. Gutierrez and other patients will be featured in a video as part of our upcoming Neglected Tropical Diseases Forum at Tulane University in Louisiana on May 15. Continue reading →

New research suggests patient’s fat cells could be used to kill brain cancer

Adipose- derived stem cells. Source: Pendleton, Li, et. al. Mesenchymal Stem Cells Derived from Adipose Tissue vs Bone Marrow:In Vitro Comparison of Their Tropism towards Gliomas.  2013. PLOSONE.

Adipose- derived stem cells. Source: Pendleton, Li, et. al. Mesenchymal Stem Cells Derived from Adipose Tissue vs Bone Marrow:In Vitro Comparison of Their Tropism towards Gliomas. 2013. PLOSONE.

Recent research from Johns Hopkins Medicine that received government support shows that stem cells isolated from a patient’s own fat may be able to deliver new treatments directly into the brain to fight an aggressive brain tumor. The work, done in the laboratory of Alfredo Quinones-Hinojosa, MD, is a proof-of-principle study that tests the ability of a particular type of stem cell, mesenchymal stem cells, to locate damaged or cancerous cells.

Cancer cells, particularly those in glioblastomas, the most common type of brain tumor, often break away from the main tumor and relocate to another area of the body.  While neurosurgeons like Quinones-Hinojosa can carefully remove these tumors, radiation and chemotherapy are often insufficient to kill these run-away cancer cells. The promising results from this basic science study suggest that in the future, mesenchymal stem cells isolated from the patient’s own fat tissue can be modified and put back into the body to seek out and destroy isolated cancer cells in the brain after surgical removal of the tumor. Continue reading →

A Weekly Advocacy Message from Mary Woolley: Misleading titles, or misunderstanding of science, or both?

Dear Research Advocate,

House of Representatives Science Committee Chair Lamar Smith’s (R-TX) proposed legislation, the “High Quality Research Act,” would undermine, rather than achieve, “high quality” in research, since it would create several new hoops for approval of NSF-funded grants. These appear to be based on the mistaken idea that science follows a linear path to a single metric for success or failure. And the bill requires the NSF director to attest in advance to the success of each funded proposal! Letters penned by former NSF directors and National Science Board chairs and former NSF assistant directors warn of the “chilling and detrimental impact” this legislation could have on the current merit-based system. In order to rebuff this outright attack on science, many more advocates must weigh in. The Coalition for National Science Funding (CNSF) will send a letter addressing the concerns of shifting away from “scientific merit” as the ultimate criteria for determining which science to fund. If you are a part of an organization that would like to sign on to this letter, please contact Sam Rankin. Or write your own. In any case, join us in taking action!

House Majority Leader Eric Cantor’s (R-VA) new bill, H.R. 1724, known as the “Kids First Research Act of 2013,” aims to “eliminate taxpayer financing of presidential campaigns and party conventions and reprogram savings to provide for a 10-year pediatric research initiative …” The bill’s text would limit scientific freedom, as Section 4 is a ban on NIH-funded health economics research. Health economics research is crucial to efficient, effective health care and health care systems, and it also has a significant role to play in ensuring the efficiency and effectiveness of research itself. Especially if you perform, benefit from or use findings from health economics research, but also if you care about the future of science, please reach out to your elected officials to call for eliminating Section 4 of H.R. 1724.

Meanwhile the details of sequestration, which we should all remember was never meant to make it into law — it is a symbol of failure, not a show of common sense — continue to emerge. On Wednesday, NIH released the FY13 Fiscal Policy for Grant Awards. To keep grant sizes roughly the same size as in FY12, there will be fewer awards. Detailed in the Mechanism Table, Research Project Grants are down 6.1% and Intramural Research has been cut by more than 4%. Total research grants are down 6.2%. This is further bad news for researchers, students and patients worldwide at a time when NIH grant awards are already at a record low.

NIH Director Francis Collins is asking for your help to spread the word about the impact of cuts to your research. Simply tweet about the impact using the hashtag #NIHSequesterImpact as Dr. Collins’ office collects and shares these stories to bring attention to the damage of sequestration. Congress needs to fix the sequestration mistake, and we need to convince them to. Speak out, even if it’s outside your comfort zone to do so!

Speaking of getting outside your comfort zone, this was my topic in the commencement address I delivered to the medical school class of 2013 at the University at Buffalo last Friday. See our blog post on my address here.

Sincerely,

Mary Woolley

Tonight: Intelligence Squared US debate titled The FDA’s Caution is Hazardous to Our Health

The Food and Drug Administration, the oldest comprehensive consumer protection agency in the U.S. federal government, is charged with protecting the public health. Under this mandate, it regulates drugs and medical devices for their safety and effectiveness. But is it a failing mandate? It’s been argued that the FDA’s long and costly approval processes stifle innovation and keep life-changing treatments from the market. When it comes to public health, is it ever OK to sacrifice safety for speed?

Research!America has asked that same question in polling over the years; most recently in August 2012. We asked 1,052 likely voters whether FDA should move more quickly despite the risks or proceed more cautiously, even if it meant delaying treatments to patients. Thirty-five percent said the FDA should move more quickly, while 25% said the opposite. (Twenty-four percent said neither, and 16% said they weren’t sure.) Continue reading →

Research into rare premature aging disorder praised as a model of “what’s right” in biomedical research

Recently, a group of scientists, clinicians and patients gathered in a suburb of Washington, DC to discuss scientific progress in the study of a rare premature aging disorder. This disease, Hutchinson-Gilford Progeria Syndrome—often referred to as HGPS or simply progeria—is one you may not have heard of, yet. But the Progeria Research Foundation and families of progeria patients have been working hard to increase awareness and raise funds for research into this rare disease that results in death at an average age of only 13. Among the list of speakers at the conference was the Director of the National Institutes of Health, Francis Collins, MD, PhD and researchers from a number of Research!America member organizations. Continue reading →

Research!America President and CEO Mary Woolley tells University at Buffalo School of Medicine Graduates to Engage in Advocacy

Woolley addresses the class of 2013. Photo courtesy of Sandy Kicman, University at Buffalo.

As commencement speaker, Research!America President and CEO  Mary Woolley challenged University at Buffalo School of Medicine and Biomedical Sciences graduates to step outside of their comfort zone and become advocates for research.

Drawing on her own personal experiences, Woolley told the nearly 150 graduates who received their degrees on May 3 how research has dramatically affected the way in which medicine is practiced—including research that proved smoking was harmful and research that revealed differences in cardiovascular health in men versus women. “It is the very function of research to show us where we’ve been wrong; to upend conventional wisdom and muster the evidence to break new ground” in medicine, Woolley noted.  Continue reading →

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