From advances in diabetes research to record approval of drugs to treat rare diseases, taxpayer funded research and the effective employment of regulatory tools played a significant role in improving the health and wellbeing of Americans in 2014. Below is a year-end roundup of research highlights and scientific achievements from the National Institutes of Health, Centers for Disease Control and Prevention, National Science Foundation, Food and Drug Administration and Agency for Healthcare Research and Quality.
- NIH 2014 Research Highlights
- CDC Year in Review: “Mission Critical”
- NSF Discoveries
- FDA’s 2014 Drug Approvals: Speeding Novel Drugs to Patients Who Need Them
- AHRQ 2014 Impact Case studies
To fuel this momentum in scientific discovery and development, policymakers must commit to robust funding for the federal health agencies and policies that support private sector innovation. Take action today and tell your elected officials to make research for health a higher national priority in the 114th Congress.
Guest contributor — HudsonAlpha Institute for Biotechnology
Thirty years ago, in December 1984, Richard Myers, a young postdoctoral scholar at the time, joined 18 other researchers at the Alta ski resort near Salt Lake City, Utah. Unbeknownst to the scientists convened there, this meeting, organized by the Department of Energy and the International Commission for Protection Against Environmental Mutagens and Carcinogens, would lay the foundation for what would soon become an international effort to sequence the entire human genome. The participants had gathered to discuss the repercussions of an event nearly 40 years earlier: was it possible to track radiation-induced mutations in the DNA of the descendants of those exposed to the atomic bomb in Hiroshima and Nagasaki? At the height of the cold war, the question was pressing. For how many generations did the echo of such radiation exposure linger?
The answer, unfortunately, was elusive. Technology at the time was too limited to accomplish such a task. But discussions at the small meeting, which came to be known as the Alta Summit, sparked one of the most massive, most successful and most expensive biological research endeavors in history — the Human Genome Project.
Now the director and president of the HudsonAlpha Institute for Biotechnology in Huntsville, Ala., Myers and the other researchers played a pivotal role in the subsequent sequencing effort. Myers co-led one of the first human genome centers in the U.S., and his lab, together with the newly formed Joint Genome Institute in Walnut Creek, Calif., was responsible for sequencing about 11 percent of the genome, including all of chromosomes 5, 16 and 19.
HudsonAlpha is continuing the mission set forth 30 years ago, to improve human lives by applying what we learn from the study of genomics to patient care and to improving our natural resources. In the 30 years since the meeting, researchers have not only learned the entire sequence of the three billion nucleotides that make up the human genome, but they’ve also sequenced thousands of other species. They’ve learned to compare and contrast genome sequences among and within species to trace evolution’s winding path, and they’ve begun to shine a light on what has been called the “dark matter” of human DNA. They’ve compared populations from around the globe to discover ethnic and racial differences critical to the success of personalized medicine, and they’ve learned new ways to improve crop productivity to feed an ever-growing world.
“The HudsonAlpha Institute rests on the foundation established by the Human Genome Project,” said Myers. “A major focus of the institute is to use the subsequent advances in sequencing technology to make a difference in human health and disease, including brain diseases, cancer, autoimmune conditions and heart disease. Last year alone we analyzed more than 2,500 whole human genomes. We collaborate with hundreds of scientists across the globe, and have launched more than 2,000 projects with groups around the world. All this was unthinkable 30 years ago.”
The scale of possibility at HudsonAlpha shows how far the technology has come. The institute recently purchased 10 ultra-high-throughput sequencers from Illumina, Inc. Together, the sequencers can sequence about 18,000 human genomes each year, at a cost of about $1,500 each.
“As always, HudsonAlpha is focused on collaboration and data sharing,” said Myers. “We don’t function as a silo; we spread the information around. We’re also heavily committed to the idea of public and private collaboration. HudsonAlpha presents a unique model of a nonprofit research institute. We actively recruit private companies to share our space, and we now have 27 here with us. There’s a lot of cross pollination that occurs, when our faculty members interact with the company researchers.
“I can’t believe how much faster and easier it’s been in the six years that I’ve been a part of HudsonAlpha. We’re extremely excited at the potential to transform human health and crop biology. We are still growing and working to be on the front of the discovery wave.”
Statement by Research!America President and CEO Mary Woolley on the Confirmation of U.S. Surgeon General Vivek Murthy
We applaud the confirmation of Dr. Vivek Murthy as U.S. surgeon general, a visionary thinker who is well-equipped to assume the role of America’s doctor. Throughout his career he has demonstrated a strong commitment to improving public health and unwillingness to accept the status quo: invaluable traits for such challenges as combating Ebola, the obesity epidemic, tobacco-related disease and other complex health issues that confront our nation. His determination to hit the ground running to address health disparities and reduce the stigma of mental health, with a clear understanding of the role of science and innovation in improving health outcomes, is also critically important to advancing public health. We look forward to working with Dr. Murthy to alleviate health threats that impact the health and well-being of all Americans.
The tiny increases included in the “Cromnibus” bill for the National Institutes of Health (NIH) and our nation’s other health research agencies are just that. The underwhelming support for the NIH, the Centers for Disease Control and Prevention, the National Science Foundation and the Food and Drug Administration following years of stagnant funding and budget cuts begs the question – how low can we go, given health threats the likes of which stand to bankrupt the nation? And the decision to flat-fund the Agency for Healthcare Research and Quality does not provide what it takes to reduce the much-complained of inefficiencies in our health care system. The pain and economic drain of one disease alone – Alzheimer’s – is not going to be effectively confronted without stronger investments in research. Every American who wants to see our nation overcome health threats, create jobs and shore up our economy for sustained prosperity must make it clear to the next Congress that it can and must do more, making research and innovation a strategic national priority.
No doubt you’ve heard of Black Friday and Cyber Monday: two days following Thanksgiving when Americans go holiday shopping in stores and online for the best bargains. But have you heard of #GivingTuesday, a day dedicated to giving back? On Tuesday, Dec. 2, organizations, families, businesses, community centers and students around the world will come together for one common purpose: to use social media to stimulate generosity and giving. Research!America is a partner of #GivingTuesday and throughout the last weeks of 2014, we will be encouraging people to support our mission by making a donation to our organization.
While #GivingTuesday is one day dedicated to encouraging people to make a donation to a cause they care about, Research!America will be using social media throughout the month of December to call people to action: under-investment in research and public health can’t continue! We hope you too will use the hashtags #GivingTuesday and #ReasonsforResearch and link to our donation page during the month of December to help us spread the word.
To view, link to or make a contribution to our donation page, visit www.researchamerica.org/supportourwork.
World AIDS day, commemorated each year on Dec 1, aims to raise awareness about the virus, encourage advocates to redouble efforts to fight the epidemic, and remember those who have died and continue to suffer from the disease.
The 2014 World AIDS day theme “Focus, Partner, Achieve: An AIDS-free Generation,” speaks to how combined efforts and collaborations can bring us closer to a cure or vaccine. For example, public and private-sector funded research led to the development of Highly Active Antiretroviral Therapy (HAART), which revolutionized the battle against HIV/AIDS according to Research!America’s HIV/AIDS fact sheet.
Medical research has played a critical role in reducing the risk of transmission and has led to new drugs that have transformed HIV/AIDS from a fatal to a chronic illness for millions worldwide. Patients like Maria Davis, professional entertainer and HIV/AIDS advocate, has benefited from advances in HIV/AIDS treatments.
Research!America member, amfAR, The Foundation for AIDS research and The Centers for Disease Control and Prevention are raising awareness on World AIDS Day by providing up-to-date resources and information describing the human and economic impact of HIV/AIDS. In FY14, U.S. federal funding to combat HIV/AIDS here and abroad and assist those affected by the disease totaled $29.5 billion, but more resources and funding are needed to tackle this global epidemic. Tell Congress that we need more funding for HIV/AIDS research today!
To find out more about the events happening on Dec. 1, visit http://aids.gov/